CARM1 and KEAP1

		CARM1	KEAP1
Description		coactivator associated arginine methyltransferase 1	kelch like ECH associated protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Nuclear Receptor Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Lysine-acetylated Histone Binding	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Regulation Of Transcription, DNA-templated Aging Positive Regulation Of Cell Population Proliferation Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Response To CAMP Regulation Of MRNA Binding Negative Regulation Of Dendrite Development	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling	Ub-specific processing proteases ROS sensing by NFE2L2 ROS sensing by NFE2L2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Dimethyl fumarate
Diseases
GWAS		C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		35 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A KEAP1 MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I	96 interacting genes: ADH5 AK4 AMER1 ANKS1A ARPC1B ASTN1 ATG5 BAD BNIP3L BPTF C2orf68 CARD10 CARM1 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DPP3 EAF1 EGFR ERBIN ERICH5 ETF1 FAM117B FBXL17 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL2 KLHL3 KPNA6 LAMC1 LAMTOR5 LONP1 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PANX1 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA RTN4R S1PR2 SDC1 SENP1 SLC5A5 SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC UBE2D1 USP15 VAC14 WDR83 WHRN ZNF121 ZNF177 ZNF266 ZSCAN32
Entrez ID		10498	9817
HPRD ID		09158	12079
Ensembl ID		ENSG00000142453	ENSG00000079999
Uniprot IDs		Q86X55	A0A024R7C0 Q14145
PDB IDs		2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C	1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A
Enriched GO Terms of Interacting Partners?
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