HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
APPL1 and RAB5A
Number of citations of the paper that reports this interaction (PubMedID
16622416
)
228
Data Source:
BioGRID
(proximity labelling technology, two hybrid, proximity labelling technology, affinity chromatography technology, pull down)
HPRD
(in vivo, in vitro)
APPL1
RAB5A
Description
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
RAB5A, member RAS oncogene family
Image
GO Annotations
Cellular Component
Ruffle
Nucleus
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Vesicle Membrane
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Early Phagosome
Macropinosome
Extracellular Exosome
Intracellular Vesicle
Ruffle
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Synaptic Vesicle
Endosome Membrane
Endomembrane System
Actin Cytoskeleton
Endocytic Vesicle
Axon
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
Early Phagosome
Somatodendritic Compartment
Melanosome
Neuronal Cell Body
Terminal Bouton
Intracellular Membrane-bounded Organelle
Axon Terminus
Membrane Raft
Phagocytic Vesicle
Extracellular Exosome
Cytoplasmic Side Of Early Endosome Membrane
Postsynaptic Early Endosome
Anchored Component Of Synaptic Vesicle Membrane
Molecular Function
Phosphatidylserine Binding
Protein Binding
Phosphatidylinositol Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Kinase B Binding
Protein-containing Complex Binding
Beta-tubulin Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
GDP Binding
Biological Process
Protein Import Into Nucleus
Cell Cycle
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Fibroblast Migration
Signaling
Adiponectin-activated Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Regulation Of Innate Immune Response
Regulation Of Glucose Import
Positive Regulation Of Glucose Import
Positive Regulation Of Melanin Biosynthetic Process
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macropinocytosis
Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Intracellular Protein Transport
Endocytosis
Phagocytosis
Regulation Of Endocytosis
Synaptic Vesicle Recycling
Viral RNA Genome Replication
Early Endosome To Late Endosome Transport
Positive Regulation Of Exocytosis
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Endosome Size
Regulation Of Filopodium Assembly
Amyloid-beta Clearance By Transcytosis
Receptor Internalization Involved In Canonical Wnt Signaling Pathway
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Autophagosome Assembly
Pathways
Caspase activation via Dependence Receptors in the absence of ligand
Synthesis of PIPs at the plasma membrane
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Prevention of phagosomal-lysosomal fusion
Factors involved in megakaryocyte development and platelet production
Drugs
L-methionine (S)-S-oxide
Guanosine-5'-Triphosphate
Guanosine-5'-Diphosphate
Diseases
GWAS
Heel bone mineral density (
30598549
)
Iris color (L* coordinate) (
30895295
)
Interacting Genes
65 interacting genes:
ADI1
ADIPOR1
ADIPOR2
AGL
AKT1
AKT2
ANKRD1
APPL2
ATP2A1
BATF3
BIN1
BRWD1
C1QTNF9
CBL
CBLB
CIPC
CMTM4
CTTNBP2
DACT1
DCC
DNM2
DOK2
DOK3
DOK7
DPYSL5
DTNA
DYSF
EGFR
FARS2
FSHR
GPC3
HDAC2
HSPB1
ID1
IMPDH2
INO80E
KLF15
KXD1
LUC7L
MAGEA9
MAGEC3
MAP3K1
MEOX1
MTA2
MYCBP2
MYH3
PIK3CA
PIK3R1
PIK3R2
PLEKHF2
PNMA5
RAB21
RAB5A
RBBP7
RHEBL1
RUVBL2
SCAPER
SH2D2A
SOCS6
SPART
TP53
TP53BP2
TRAF2
UBE2O
ZNF829
35 interacting genes:
AGTR1
ALS2CL
ANKFY1
APPL1
APPL2
CHML
EEA1
GDI2
GRIK4
HTATIP2
ITSN1
NME2
OCRL
RAB37
RABAC1
RABEP1
RABEP2
RABGGTB
RASA1
RBSN
RIN1
RIN2
RIN3
RIT2
RUFY1
SDCBP
SGSM3
STX4
TBC1D15
TBC1D17
TBC1D3C
TBC1D3F
TRIM14
TSC2
USP6NL
Entrez ID
26060
5868
HPRD ID
05053
01542
Ensembl ID
ENSG00000157500
ENSG00000144566
Uniprot IDs
Q9UKG1
A0A024R2K1
P20339
PDB IDs
2EJ8
2ELA
2ELB
2Q12
2Q13
2Z0N
2Z0O
5C5B
1N6H
1N6I
1N6K
1N6L
1N6N
1N6O
1N6P
1N6R
1R2Q
1TU3
1TU4
3MJH
4Q9U
7BL1
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?