IBTK and LAMTOR3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		IBTK	LAMTOR3
Description		inhibitor of Bruton tyrosine kinase	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex
	Molecular Function	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Tyrosine Kinase Activity	Positive Regulation Of TOR Signaling Positive Regulation Of Kinase Activity Cellular Protein Localization Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction
Pathways			Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Central corneal thickness ( 31798171 29760442) Corneal resistance factor ( 32716492) Corneal structure ( 23291589) Coronary artery disease ( 33020668) Intraocular pressure ( 29617998 29235454)	Mean reticulocyte volume ( 32888494)
Interacting Genes		6 interacting genes: BTK LAMTOR3 PDCD4 PPP1CA PRKCB PRKD1	20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4
Entrez ID		25998	8649
HPRD ID		12105	04485
Ensembl ID		ENSG00000005700	ENSG00000109270
Uniprot IDs		B7ZLE0 E7EPI0 Q9P2D0	Q9UHA4
PDB IDs			1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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