LAMTOR3 and TFE3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LAMTOR3	TFE3
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	transcription factor binding to IGHM enhancer 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of TOR Signaling Positive Regulation Of Kinase Activity Cellular Protein Localization Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction	Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Cold-induced Thermogenesis
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)
Interacting Genes		20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4	10 interacting genes: E2F3 HMGB1 LAMTOR3 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG
Entrez ID		8649	7030
HPRD ID		04485	02439
Ensembl ID		ENSG00000109270	ENSG00000068323
Uniprot IDs		Q9UHA4	A0A024QZ23 B4DIA5 P19532
PDB IDs		1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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