LAMTOR3 and APOL6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LAMTOR3	APOL6
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	apolipoprotein L6
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex	Extracellular Region Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity	Protein Binding Lipid Binding
	Biological Process	Positive Regulation Of TOR Signaling Positive Regulation Of Kinase Activity Cellular Protein Localization Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction	Lipid Transport Lipoprotein Metabolic Process
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	HDL cholesterol levels ( 32203549) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4	10 interacting genes: ADAMTSL4 CCN3 FNTB GMCL1 KPNA3 KRTAP10-8 LAMTOR3 MTNR1B RGS13 TEPSIN
Entrez ID		8649	80830
HPRD ID		04485	06266
Ensembl ID		ENSG00000109270	ENSG00000221963
Uniprot IDs		Q9UHA4	B3KTP4 Q9BWW8
PDB IDs		1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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