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KANK2 and HAND2
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
KANK2
HAND2
Description
KN motif and ankyrin repeat domains 2
heart and neural crest derivatives expressed 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Chromatin
Nucleus
Transcription Regulator Complex
Protein-containing Complex
Molecular Function
Protein Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
E-box Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Regulation Of Rho Protein Signal Transduction
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Vitamin D Receptor Signaling Pathway
Kidney Epithelium Development
Glomerular Visceral Epithelial Cell Migration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Angiogenesis
In Utero Embryonic Development
Heart Looping
Suckling Behavior
Cardiac Right Ventricle Formation
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Apoptotic Process Involved In Heart Morphogenesis
Noradrenergic Neuron Differentiation
Regulation Of Transcription By RNA Polymerase II
Heart Development
Adult Heart Development
Mesenchymal Cell Proliferation
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Developmental Process
Regulation Of Tissue Remodeling
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Tongue Development
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Thymus Development
Peripheral Nervous System Neuron Development
Cartilage Morphogenesis
Coronary Artery Morphogenesis
Visceral Serous Pericardium Development
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Cell Proliferation Involved In Outflow Tract Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of P38MAPK Cascade
Primary Palate Development
Positive Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process
Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis
Pathways
Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
29212778
)
HDL cholesterol (
23505323
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Intraocular pressure (
31959993
)
Low density lipoprotein cholesterol levels (
32902719
32154731
)
Mean spheric corpuscular volume (
32888494
)
NHDL cholesterol levels (
32902719
)
Red cell distribution width (
32888494
27863252
28957414
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Triglyceride levels (
32203549
)
Atrial fibrillation (
28416822
30061737
29892015
)
Chin dimples (
27182965
)
Early onset atrial fibrillation (
28460022
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Epstein-Barr virus copy number in lymphoblastoid cell lines (
28654678
)
PR interval (
32439900
)
Interacting Genes
185 interacting genes:
ABI3
AEN
ANKRD11
AP2B1
ARL14EP
ASB15
BEND7
BIRC7
BLZF1
BORCS6
C11orf1
C2orf68
CADPS
CAMK2G
CAPN3
CARD10
CARD9
CBX8
CCDC33
CCDC57
CCDC88B
CDC20B
CDC5L
CDKL3
CEACAM6
CEP55
CEP63
CEP70
CHCHD3
CHIC2
CINP
COG6
CRX
CSNK2A1
CUTC
CWF19L2
CYTH4
DDIT4L
DLGAP3
DPEP2NB
DTX2
DYNLL1
DYNLL2
EFHC2
EIF4E
ELOA
EXOSC8
FAM161A
FAM90A1
FHL2
FHL3
FKBP6
GADD45GIP1
GATA1
GEMIN4
GKAP1
GMCL1
GMNN
GOLGA2
GOLGA6A
GOLGA6L9
GPANK1
GPKOW
GPSM1
GRB10
HAND2
HOMER3
HSF2BP
HSPB2
HSPB2-C11orf52
IHO1
IKZF3
IL16
KIF9
KIFAP3
KIFC3
KRT27
KRT34
KRT40
KRT75
KRT86
KRTAP6-3
L3MBTL3
LBX1
LENG1
LHX1
LHX3
LMO1
LMO2
LMO3
LMO4
LZTS1
MAGEB4
MCCD1
MCRS1
MED19
MEOX1
MEOX2
MID2
MITD1
MKRN3
MOB1A
MOB3C
MORN3
MSS51
MTUS2
MYOZ3
NCOA1
NCOA5
NECAB2
NOS3
NUTM1
OIP5
PAX6
PCBD1
PDE9A
PDLIM7
PFDN6
PIBF1
PLAGL2
PLEKHA2
PNKP
PPP1CB
PRDM14
PRDM6
PRKAR1B
PRMT5
PRPF18
PRPF31
PRR5L
PSEN1
PSMB4
PSTPIP1
RAB11FIP2
RALBP1
RBCK1
RHOH
SCARA5
SCNM1
SERTAD3
SNAPIN
SNW1
SORBS3
SRPK2
STAC
SYT6
TAX1BP1
TEX11
TFIP11
TGM5
THAP1
THAP6
TIFA
TLE5
TOP3B
TRAF1
TRAF2
TRAF4
TRIB3
TRIM35
TRIM54
TSGA10
TSGA10IP
TSPYL6
TXLNA
UBAP2
USHBP1
UTP14C
VMAC
VPS52
VWC2
WASF3
WASHC1
ZBTB42
ZFP57
ZMAT2
ZMYND12
ZNF212
ZNF414
ZNF512
ZNF648
ZNF774
ZNF784
ZNHIT1
ZRANB1
22 interacting genes:
CENPB
COPS5
DNMT3L
EP300
FAM90A1
GATA4
HAND1
HEY2
HEYL
KANK2
NEK1
NPM1
PHOX2A
PPP2R5D
PRKACA
PRKCA
RIPPLY1
SPANXN3
TCF12
TCF3
TCF4
USP20
Entrez ID
25959
9464
HPRD ID
12463
03872
Ensembl ID
ENSG00000197256
ENSG00000164107
Uniprot IDs
Q63ZY3
P61296
PDB IDs
4HBD
5YBV
6TMD
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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