HAND2 and SPANXN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HAND2	SPANXN3
Description		heart and neural crest derivatives expressed 2	SPANX family member N3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Transcription Factor Binding Protein Homodimerization Activity E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Heart Looping Suckling Behavior Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Regulation Of Transcription By RNA Polymerase II Heart Development Adult Heart Development Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Developmental Process Regulation Of Tissue Remodeling Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Thymus Development Peripheral Nervous System Neuron Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of P38MAPK Cascade Primary Palate Development Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis
Pathways		Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416822 30061737 29892015) Chin dimples ( 27182965) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) PR interval ( 32439900)	Creatine kinase levels ( 29403010)
Interacting Genes		22 interacting genes: CENPB COPS5 DNMT3L EP300 FAM90A1 GATA4 HAND1 HEY2 HEYL KANK2 NEK1 NPM1 PHOX2A PPP2R5D PRKACA PRKCA RIPPLY1 SPANXN3 TCF12 TCF3 TCF4 USP20	17 interacting genes: APP ATP6V1C2 CAVIN1 CEP70 FAM217B FAM228A HAND2 MEOX2 NEDD4 PBX4 PTGES3L-AARSD1 SDCBP SP4 STAC3 YAF2 ZNF143 ZNF76
Entrez ID		9464	139067
HPRD ID		03872	18092
Ensembl ID		ENSG00000164107	ENSG00000189252
Uniprot IDs		P61296	Q5MJ09
PDB IDs
Enriched GO Terms of Interacting Partners?
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