PRDX5 and CDKN2D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRDX5	CDKN2D
Description		peroxiredoxin 5	cyclin dependent kinase inhibitor 2D
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cyclin D2-CDK4 Complex
	Molecular Function	RNA Polymerase III Transcription Regulatory Region Sequence-specific DNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Apoptotic Process Inflammatory Response Response To Oxidative Stress Negative Regulation Of Transcription By RNA Polymerase III Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Redox Homeostasis Cellular Oxidant Detoxification	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Response To UV Negative Regulation Of Cell Growth Response To Retinoic Acid Response To Vitamin D Negative Regulation Of Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Autophagic Cell Death Regulation Of Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle G1/S Phase Transition
Pathways			Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs		Auranofin Diminazene
Diseases
GWAS		Alopecia areata ( 20596022 25608926) Crohn's disease ( 28067908 21102463) Multiple sclerosis ( 31604244 24076602) Psoriasis ( 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Psoriasis vulgaris ( 26626624) Sarcoidosis ( 22837380) Vitiligo ( 27723757)	Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		10 interacting genes: APP CCDC90B CDKN2D CLK1 ERBB2 ERBB3 ERBB4 NUFIP2 PEX5 SMCP	63 interacting genes: APP BRCA1 BTG1 C1orf94 C5orf49 CCND3 CDK4 CDK6 CGGBP1 CTBP1 DDIT4L DMRTB1 DYNLT2B EIF4G1 FAM228A FAM86C1P FHL3 GATAD2B GLYR1 GORASP2 GSC2 HSD17B14 IKZF3 INCA1 KRT75 LNX1 LONRF1 LSM3 MEI4 MEOX2 MSS51 MTF2 NDUFB7 NIF3L1 NME4 NMI NR4A1 NR4A2 NR4A3 PICK1 PRDX5 PRIMPOL PSMA1 QKI REL RUFY4 SAXO1 SDCBP SH3GLB1 SH3GLB2 TBC1D17 TEX11 THAP1 TSG101 TSGA10IP UQCC2 VGLL1 YPEL3 ZBTB32 ZNF396 ZNF620 ZNF688 ZNF774
Entrez ID		25824	1032
HPRD ID		05958	02957
Ensembl ID		ENSG00000126432	ENSG00000129355
Uniprot IDs		P30044	A0A024R796 P55273
PDB IDs		1H4O 1HD2 1OC3 1URM 2VL2 2VL3 2VL9 3MNG 4K7I 4K7N 4K7O 4MMM	1BD8 1BI8
Enriched GO Terms of Interacting Partners?
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