CDKN2D and CDK4

Number of citations of the paper that reports this interaction (PubMedID 7739548)
58

Data Source:
HPRD (in vivo, in vitro)

		CDKN2D	CDK4
Description		cyclin dependent kinase inhibitor 2D	cyclin dependent kinase 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cyclin D2-CDK4 Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Bicellular Tight Junction Mediator Complex Nuclear Membrane Perinuclear Region Of Cytoplasm Cyclin D2-CDK4 Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein-containing Complex Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Response To UV Negative Regulation Of Cell Growth Response To Retinoic Acid Response To Vitamin D Negative Regulation Of Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Autophagic Cell Death Regulation Of Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle G1/S Phase Transition	G1/S Transition Of Mitotic Cell Cycle Lens Development In Camera-type Eye Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Population Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Animal Organ Regeneration Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Insulin Receptor Signaling Pathway Regulation Of Lipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Catalytic Activity Regulation Of Lipid Catabolic Process Cell Division Regulation Of Cell Cycle Response To Hyperoxia Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs			Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		63 interacting genes: APP BRCA1 BTG1 C1orf94 C5orf49 CCND3 CDK4 CDK6 CGGBP1 CTBP1 DDIT4L DMRTB1 DYNLT2B EIF4G1 FAM228A FAM86C1P FHL3 GATAD2B GLYR1 GORASP2 GSC2 HSD17B14 IKZF3 INCA1 KRT75 LNX1 LONRF1 LSM3 MEI4 MEOX2 MSS51 MTF2 NDUFB7 NIF3L1 NME4 NMI NR4A1 NR4A2 NR4A3 PICK1 PRDX5 PRIMPOL PSMA1 QKI REL RUFY4 SAXO1 SDCBP SH3GLB1 SH3GLB2 TBC1D17 TEX11 THAP1 TSG101 TSGA10IP UQCC2 VGLL1 YPEL3 ZBTB32 ZNF396 ZNF620 ZNF688 ZNF774	148 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CA10 CAMK1 CAPN1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 CTDSP2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GNS GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AA1 IFI27 IFNG IGF1R IKZF3 IL15RA INCA1 IRF7 KDELR2 LATS2 LNX2 LUC7L2 LY75 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYC MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL OPTN ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RAP2A RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RNF139 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP15 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655
Entrez ID		1032	1019
HPRD ID		02957	00447
Ensembl ID		ENSG00000129355	ENSG00000135446
Uniprot IDs		A0A024R796 P55273	A0A024RBB6 P11802
PDB IDs		1BD8 1BI8	1LD2 2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H
Enriched GO Terms of Interacting Partners?
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