SLC39A6 and BCL2L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC39A6	BCL2L2
Description		solute carrier family 39 member 6	BCL2 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Lamellipodium Membrane	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex
	Molecular Function	Zinc Ion Transmembrane Transporter Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding
	Biological Process	Cellular Zinc Ion Homeostasis Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Zinc influx into cells by the SLC39 gene family
Drugs			Navitoclax
Diseases
GWAS		Esophageal squamous cell cancer (length of survival) ( 23644492)	Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: BCL2L2 MTNR1B RETREG3 SLC10A6 SPP1 TMEM31	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		25800	599
HPRD ID		12285	03569
Ensembl ID		ENSG00000141424	ENSG00000129473
Uniprot IDs		Q13433	Q92843
PDB IDs			1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?
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