IL27 and IL27RA

Number of citations of the paper that reports this interaction (PubMedID 12121660)
437

Data Source:
HPRD (in vitro, in vivo)

		IL27	IL27RA
Description		interleukin 27	interleukin 27 receptor subunit alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Interleukin-27 Receptor Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Inflammatory Response Signal Transduction Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of T Cell Proliferation Innate Immune Response Regulation Of T-helper 1 Cell Differentiation	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways		Interleukin-27 signaling Interleukin-27 signaling	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Ankylosing spondylitis ( 23749187) Blood protein levels ( 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062 29273807) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 28166215) Crohn's disease ( 30500874 28067908 21102463 32581322) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 1 diabetes ( 21829393 25751624 19430480)	Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		1 interacting genes: IL27RA	13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6
Entrez ID		246778	9466
HPRD ID		16307	09247
Ensembl ID		ENSG00000197272	ENSG00000104998
Uniprot IDs		Q8NEV9	Q6UWB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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