IFIT5 and PRDX2

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		IFIT5	PRDX2
Description		interferon induced protein with tetratricopeptide repeats 5	peroxiredoxin 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Actin Cytoskeleton Ruffle Membrane Apical Part Of Cell	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	TRNA Binding RNA Cap Binding Double-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity
	Biological Process	Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interferon alpha/beta signaling	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS			Platelet distribution width ( 32888494)
Interacting Genes		17 interacting genes: A2M APOE CDC37 CHUK ECSIT IFIT1 IFIT3 IKBKG LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2	25 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 TYK2 UTY YWHAZ
Entrez ID		24138	7001
HPRD ID		17130	02763
Ensembl ID		ENSG00000152778	ENSG00000167815
Uniprot IDs		Q13325	P32119 V9HW12
PDB IDs		3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U	1QMV 5B8A 5B8B 5IJT
Enriched GO Terms of Interacting Partners?
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