KCNE5 and PGRMC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KCNE5	PGRMC1
Description		potassium voltage-gated channel subfamily E regulatory subunit 5	progesterone receptor membrane component 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex	Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Amyloid-beta Binding Steroid Binding Protein Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Regulation Of Heart Contraction Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Cation Channel Activity	Heme Biosynthetic Process
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Neutrophil degranulation
Drugs		Enflurane Promethazine Miconazole	Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS			Hodgkin's lymphoma ( 34216518)
Interacting Genes		7 interacting genes: APP GET3 KCNB1 KCNG4 PGRMC1 SGTA SGTB	21 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 MTNR1A MX1 PAM16 PGRMC2 SCAP SGTB TMEM213 ZNF71
Entrez ID		23630	10857
HPRD ID		02268	02338
Ensembl ID		ENSG00000176076	ENSG00000101856
Uniprot IDs		Q9UJ90	O00264 Q6IB11
PDB IDs			4X8Y
Enriched GO Terms of Interacting Partners?
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