TMEM50A and HLA-DPA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM50A	HLA-DPA1
Description		transmembrane protein 50A	major histocompatibility complex, class II, DP alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane Neuronal Cell Body Glial Cell Projection	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Cellular Response To Interferon-gamma
Pathways			Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases
GWAS		Erythrocyte sedimentation rate ( 21700265) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Asthma ( 30929738 31619474) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hepatitis B ( 21750111) Hepatitis B (viral clearance) ( 22737229) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Mortality in sepsis ( 27639821) Myositis ( 26291516) Nephropathy ( 21399633) Persistent hepatitis B virus infection ( 33736632) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 29534301) SjÃ¶gren's syndrome ( 24097066) Systemic lupus erythematosus ( 32771030) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		13 interacting genes: ABCG4 AQP6 COMT HLA-DPA1 LEPROT LEPROTL1 REEP4 SLC30A8 SYT9 TMEM14B TMEM31 TRAPPC14 XRN1	6 interacting genes: CD4 CD74 CNMD HLA-DPB1 TMEM50A TMEM50B
Entrez ID		23585	3113
HPRD ID		05636	00835
Ensembl ID		ENSG00000183726	ENSG00000231389
Uniprot IDs		B7Z5M7 O95807 Q7RU07	P20036 X5CKE2
PDB IDs			3LQZ 4P4K 4P4R 4P57 4P5K 4P5M
Enriched GO Terms of Interacting Partners?
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