HEY1 and YTHDF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HEY1	YTHDF1
Description		hes related family bHLH transcription factor with YRPW motif 1	YTH N6-methyladenosine RNA binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	P-body Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Notch Signaling Involved In Heart Development Negative Regulation Of Biomineral Tissue Development Cellular Response To Glucocorticoid Stimulus Circulatory System Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis	Immune System Process Regulation Of Antigen Processing And Presentation Learning Memory Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation MRNA Destabilization Organelle Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of Axon Guidance
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699)	Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		24 interacting genes: ARNT CREBZF DAZAP2 FBXW7 FOXH1 GATA1 HES1 HEY2 KRTAP6-2 LAPTM5 MDM2 MYOD1 NTRK3 PITX2 PLEKHB2 PLEKHF2 PRKD2 SKIL SMAD3 SMAD9 TENT5D THTPA TP53 YTHDF1	19 interacting genes: ABHD11 BATF2 C6orf15 FAM168A HEY1 HSF4 ITSN2 KRTAP13-1 KRTAP26-1 KRTAP7-1 KRTAP8-1 LASP1 MAGED1 MSX2 OIP5 PRR32 TLE5 VPS37C ZNF34
Entrez ID		23462	54915
HPRD ID		04260	11691
Ensembl ID		ENSG00000164683	ENSG00000149658
Uniprot IDs		B4DEI9 Q9Y5J3	Q9BYJ9
PDB IDs		2DB7	4RCI 4RCJ
Enriched GO Terms of Interacting Partners?
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