HEY1 and THTPA

		HEY1	THTPA
Description		hes related family bHLH transcription factor with YRPW motif 1	thiamine triphosphatase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding Protein Binding Hydrolase Activity Thiamin-triphosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Notch Signaling Involved In Heart Development Negative Regulation Of Biomineral Tissue Development Cellular Response To Glucocorticoid Stimulus Circulatory System Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis	Generation Of Precursor Metabolites And Energy Thiamine Metabolic Process Dephosphorylation Thiamine Diphosphate Metabolic Process
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Vitamin B1 (thiamin) metabolism
Drugs
Diseases
GWAS		Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699)
Interacting Genes		24 interacting genes: ARNT CREBZF DAZAP2 FBXW7 FOXH1 GATA1 HES1 HEY2 KRTAP6-2 LAPTM5 MDM2 MYOD1 NTRK3 PITX2 PLEKHB2 PLEKHF2 PRKD2 SKIL SMAD3 SMAD9 TENT5D THTPA TP53 YTHDF1	8 interacting genes: DPAGT1 GCDH HEY1 METTL17 OR4K5 PDE6B RNASE7 TLX3
Entrez ID		23462	79178
HPRD ID		04260	15505
Ensembl ID		ENSG00000164683	ENSG00000259431
Uniprot IDs		B4DEI9 Q9Y5J3	G3V5Q5 Q9BU02
PDB IDs		2DB7	3BHD 3TVL
Enriched GO Terms of Interacting Partners?
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