HSPD1 and MGAT3

		HSPD1	MGAT3
Description		heat shock protein family D (Hsp60) member 1	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Peroxisomal Matrix Rough Endoplasmic Reticulum Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Mitochondrial Crista Coated Vesicle Secretory Granule Golgi Cisterna Protein-containing Complex Zymogen Granule Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece	Golgi Membrane Integral Component Of Membrane
	Molecular Function	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Chaperone Binding Modification-dependent Protein Binding	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase Activity Protein Binding Glycosyltransferase Activity
	Biological Process	Response To Hypoxia MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Ischemia Protein Folding 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Response To Xenobiotic Stimulus Response To Activity Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To ATP Mitochondrial Unfolded Protein Response Cellular Response To Heat Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Response To Cocaine Response To Hydrogen Peroxide Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Response To Glucocorticoid Protein Maturation Biological Process Involved In Interaction With Symbiont Negative Regulation Of Apoptotic Process In Bone Marrow Cell Cellular Response To Interleukin-7 Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	N-acetylglucosamine Metabolic Process Protein N-linked Glycosylation Protein Localization Regulation Of Cell Migration Cellular Response To Oxidative Stress Amyloid-beta Metabolic Process Cognition Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Lysosomal Protein Catabolic Process
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Reactions specific to the hybrid N-glycan synthesis pathway
Drugs		Copper
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	General cognitive ability ( 29844566) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Post bronchodilator FEV1 ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656) Sleep duration (short sleep) ( 30846698)
Interacting Genes		61 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP6 CASP9 CEP70 CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT GLI2 H2BC21 HSPE1 ITGA3 ITGB1 KCTD10 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 MGAT3 MOB4 NOS1AP NOTCH2NLA NR3C1 OGT PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SF3B1 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG	2 interacting genes: HSPD1 UBAC1
Entrez ID		3329	4248
HPRD ID		00318	07058
Ensembl ID		ENSG00000144381	ENSG00000128268
Uniprot IDs		A0A024R3X4 P10809	Q09327
PDB IDs		4PJ1 6HT7 6MRC 6MRD 7AZP
Enriched GO Terms of Interacting Partners?
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