SIK2 and CRTC2

Number of citations of the paper that reports this interaction (PubMedID 15454081)
261

Data Source:
BioGRID (imaging technique)
HPRD (in vivo, in vitro)

		SIK2	CRTC2
Description		salt inducible kinase 2	CREB regulated transcription coactivator 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Chromatin Binding Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Protein Phosphorylation Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Toxin Transport
Pathways			Transcriptional activation of mitochondrial biogenesis Circadian Clock Heme signaling
Drugs		Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Primary sclerosing cholangitis ( 23603763 27992413) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age at first birth ( 34211149 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: APP CRTC2 CRTC3 FBXW7 GABARAPL2 HDAC5 IRS1	14 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ
Entrez ID		23235	200186
HPRD ID		12348	12347
Ensembl ID		ENSG00000170145	ENSG00000160741
Uniprot IDs		A0A024R3G7 Q9H0K1	Q53ET0
PDB IDs			4HTM
Enriched GO Terms of Interacting Partners?
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