SIK2 and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SIK2	GABARAPL2
Description		salt inducible kinase 2	GABA type A receptor associated protein like 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Vesicle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	SNARE Binding Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Protein Phosphorylation Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation	Autophagosome Assembly Autophagy Of Mitochondrion Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Macroautophagy Positive Regulation Of ATPase Activity Protein Localization To Endoplasmic Reticulum Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Macroautophagy TBC/RABGAPs
Drugs		Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Primary sclerosing cholangitis ( 23603763 27992413) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		7 interacting genes: APP CRTC2 CRTC3 FBXW7 GABARAPL2 HDAC5 IRS1	91 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 BCL2L13 BNIP3L BSDC1 CALCOCO1 CALCOCO2 CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPM6A GPR37 HAP1 HSP90AB1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP1LC3B MCPH1 MEFV MLX NBR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PRKAR2A PTPRA RAP1A RAP2A RB1CC1 RCN2 RETREG1 RETREG3 RPS2 SCYL3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		23235	11345
HPRD ID		12348	16246
Ensembl ID		ENSG00000170145	ENSG00000034713
Uniprot IDs		A0A024R3G7 Q9H0K1	P60520
PDB IDs			4CO7 6H8C
Enriched GO Terms of Interacting Partners?
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