CRTC2 and SIK2

Number of citations of the paper that reports this interaction (PubMedID 15454081)
261

Data Source:
BioGRID (imaging technique)
HPRD (in vivo, in vitro)

		CRTC2	SIK2
Description		CREB regulated transcription coactivator 2	salt inducible kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome	Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding CAMP Response Element Binding Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Toxin Transport	Protein Phosphorylation Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock Heme signaling
Drugs			Fostamatinib
Diseases
GWAS		Age at first birth ( 34211149 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Primary sclerosing cholangitis ( 23603763 27992413) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ	7 interacting genes: APP CRTC2 CRTC3 FBXW7 GABARAPL2 HDAC5 IRS1
Entrez ID		200186	23235
HPRD ID		12347	12348
Ensembl ID		ENSG00000160741	ENSG00000170145
Uniprot IDs		Q53ET0	A0A024R3G7 Q9H0K1
PDB IDs		4HTM
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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