FAF2 and PNPLA2

Number of citations of the paper that reports this interaction (PubMedID 23297223)
76

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		FAF2	PNPLA2
Description		Fas associated factor family member 2	patatin like phospholipase domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lipid Droplet VCP-NPL4-UFD1 AAA ATPase Complex Azurophil Granule Lumen	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity	Lipoprotein Lipase Activity Triglyceride Lipase Activity Acylglycerol O-acyltransferase Activity Retinyl-palmitate Esterase Activity
	Biological Process	Response To Unfolded Protein Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Negative Regulation Of Catalytic Activity	Diacylglycerol Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis
Pathways		Neutrophil degranulation RHOA GTPase cycle	Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Cirrhosis (alcohol related) ( 32853455)	Body fat distribution (arm fat ratio) ( 30664634) Body shape index ( 34021172) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Keratoconus ( 31855235) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ELAVL1 FAF1 FAS MAP3K1 OGT PCAT1 PNPLA2 PSMD2 SMURF1 STC2 UBE2D1 UBE3A VCP	10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		23197	57104
HPRD ID		16870	11443
Ensembl ID		ENSG00000113194	ENSG00000177666
Uniprot IDs		Q96CS3	Q96AD5
PDB IDs		2DAM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?