FLII and MAPK7

		FLII	MAPK7
Description		FLII actin remodeling protein	mitogen-activated protein kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Brush Border Focal Adhesion Actin Cytoskeleton Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Actin Polymerization Or Depolymerization Myofibril Assembly Actin Filament Severing Barbed-end Actin Filament Capping	MAPK Cascade Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs			Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS			Alzheimer's disease ( 30636644)
Interacting Genes		14 interacting genes: ACTB ACTL6A CARM1 DLST ESR1 GRIP1 LRRFIP1 LRRFIP2 MAPK7 MYD88 NCOA2 OPTN PRMT1 TRAIP	37 interacting genes: ACTN4 ADI1 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FLII FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K4 MAP2K5 MEF2A MEF2C MEF2D MFAP4 MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RASGRP1 RXRA SGK1 SH2D2A SREBF1 UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1
Entrez ID		2314	5598
HPRD ID		02647	03952
Ensembl ID		ENSG00000177731	ENSG00000166484
Uniprot IDs		Q13045	A0A024QZ20 Q13164
PDB IDs			2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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