MAPK7 and ELK4

Number of citations of the paper that reports this interaction (PubMedID 10473620)
151

Data Source:
HPRD (in vivo, in vitro)

		MAPK7	ELK4
Description		mitogen-activated protein kinase 7	ETS transcription factor ELK4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3 Deacetylation
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs		Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644)
Interacting Genes		37 interacting genes: ACTN4 ADI1 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FLII FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K4 MAP2K5 MEF2A MEF2C MEF2D MFAP4 MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RASGRP1 RXRA SGK1 SH2D2A SREBF1 UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1	12 interacting genes: BRCA1 FGFR2 FOS ID1 ID2 ID3 MAPK1 MAPK11 MAPK3 MAPK7 MAPK8 SRF
Entrez ID		5598	2005
HPRD ID		03952	02592
Ensembl ID		ENSG00000166484	ENSG00000158711
Uniprot IDs		A0A024QZ20 Q13164	A0A024R985 A0A024R997 P28324 Q8IXL1
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN	1BC7 1BC8 1HBX 1K6O
Enriched GO Terms of Interacting Partners?
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