IGHG1 and FCGR3B

Number of citations of the paper that reports this interaction (PubMedID 10917521)
222

Data Source:
HPRD (in vitro)

		IGHG1	FCGR3B
Description		immunoglobulin heavy constant gamma 1 (G1m marker)	Fc fragment of IgG receptor IIIb
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Blood Microparticle	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane Anchored Component Of Membrane Extracellular Exosome
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding	Transmembrane Signaling Receptor Activity IgG Binding
	Biological Process	Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation	Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Immune Response
Pathways			Post-translational modification: synthesis of GPI-anchored proteins Neutrophil degranulation
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Muromonab Alemtuzumab Alefacept Natalizumab Palivizumab Daclizumab Catumaxomab Sarilumab
Diseases
GWAS		Blood protein levels ( 29875488) Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)	Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Limited cutaneous systemic scleroderma ( 29293537) Monocyte count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systemic lupus erythematosus ( 26502338) Systemic sclerosis (anti-centromere-positive) ( 29293537) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5	2 interacting genes: APCS IGHG1
Entrez ID		3500	2215
HPRD ID		11755	09951
Ensembl ID		ENSG00000211896	ENSG00000162747
Uniprot IDs			A0A087WU90 A0A087WZR4 A0A3B3ISU3 O75015
PDB IDs			1E4J 1E4K 1FNL 1T83 1T89 6EAQ
Enriched GO Terms of Interacting Partners?
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