NCOA6 and TGS1

Number of citations of the paper that reports this interaction (PubMedID 11517327)
40

Data Source:
HPRD (in vitro, in vivo)

		NCOA6	TGS1
Description		nuclear receptor coactivator 6	trimethylguanosine synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle	Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Small Nuclear Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding RNA Methyltransferase Activity RNA Trimethylguanosine Synthase Activity
	Biological Process	DNA-templated Transcription, Initiation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Spliceosomal SnRNP Assembly 7-methylguanosine RNA Capping Ribonucleoprotein Complex Biogenesis 7-methylguanosine Cap Hypermethylation
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis Cytoprotection by HMOX1 Heme signaling	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression snRNP Assembly PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Cytoprotection by HMOX1 Heme signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling nervous ( 29500382) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Gut microbiota (bacterial taxa) ( 27723756) Height ( 18391951) Serum thyroid-stimulating hormone levels ( 24852370)
Interacting Genes		65 interacting genes: AAR2 AR ARID1B ASCC1 ASXL1 ATF2 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 H3C14 HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335	9 interacting genes: ANKRD28 COIL CREBBP EED EP300 HNF4A NCOA6 NOXA1 ZNF76
Entrez ID		23054	96764
HPRD ID		05599	07567
Ensembl ID		ENSG00000198646	ENSG00000137574
Uniprot IDs		F6M2K2 F6M2K3 Q14686	Q96RS0
PDB IDs			3EGI 3GDH
Enriched GO Terms of Interacting Partners?
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