NCOA6 and ZNF335

Number of citations of the paper that reports this interaction (PubMedID 12215545)
16

Data Source:
HPRD (in vitro, in vivo)

		NCOA6	ZNF335
Description		nuclear receptor coactivator 6	zinc finger protein 335
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	DNA-templated Transcription, Initiation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Brain Development Regulation Of Gene Expression Cerebral Cortex Neuron Differentiation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Morphogenesis Brain Morphogenesis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Neurogenesis Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis Cytoprotection by HMOX1 Heme signaling	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling nervous ( 29500382) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Abdominal aortic aneurysm ( 27899403) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Celiac disease ( 25920553) Coronary artery disease ( 29212778 33020668) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862)
Interacting Genes		65 interacting genes: AAR2 AR ARID1B ASCC1 ASXL1 ATF2 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 H3C14 HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335	5 interacting genes: CCAR2 CDK4 CDK6 HSPB2 NCOA6
Entrez ID		23054	63925
HPRD ID		05599	11709
Ensembl ID		ENSG00000198646	ENSG00000198026
Uniprot IDs		F6M2K2 F6M2K3 Q14686	Q8IW09 Q9H4Z2
PDB IDs
Enriched GO Terms of Interacting Partners?
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