RIMS1 and ERC1

Number of citations of the paper that reports this interaction (PubMedID 12391317)
81

Data Source:
HPRD (two hybrid, in vitro)

		RIMS1	ERC1
Description		regulating synaptic membrane exocytosis 1	ELKS/RAB6-interacting/CAST family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone	Golgi Membrane Cytoplasm Centrosome IkappaB Kinase Complex Ciliary Basal Body Presynaptic Membrane Synapse Cytoskeleton Of Presynaptic Active Zone
	Molecular Function	RNA Binding Protein Binding GTPase Regulator Activity Small GTPase Binding Transmembrane Transporter Binding Metal Ion Binding	Protein Binding PDZ Domain Binding Small GTPase Binding Leucine Zipper Domain Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Intracellular Protein Transport Visual Perception Positive Regulation Of Gene Expression Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Cell Differentiation Regulation Of Membrane Potential Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Positive Regulation Of Synaptic Transmission Response To Stimulus Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Positive Regulation Of Excitatory Postsynaptic Potential	Regulation Of Transcription, DNA-templated I-kappaB Phosphorylation Neuromuscular Synaptic Transmission Multicellular Organism Development Protein Transport Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 29483656 30285260) Squamous cell lung carcinoma ( 28604730) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32203549)	Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: CACNA1B CACNA1C CAMK2A COL9A1 ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B VAV1 YWHAH	19 interacting genes: APP CD163 CRIP1 DNAJC5 FGF23 FPR2 GALNT8 GPRC5D IFFO1 ITSN2 MRTFB NCAPD2 PPFIA1 PRMT8 RAB6A RAB6B RIMS1 SRPK2 YWHAG
Entrez ID		22999	23085
HPRD ID		09435	06181
Ensembl ID		ENSG00000079841	ENSG00000082805
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	G8JLD3 Q8IUD2 X6RLX0
PDB IDs		2CSS
Enriched GO Terms of Interacting Partners?
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