ERC1 and CD163

		ERC1	CD163
Description		ELKS/RAB6-interacting/CAST family member 1	CD163 molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Centrosome IkappaB Kinase Complex Ciliary Basal Body Presynaptic Membrane Synapse Cytoskeleton Of Presynaptic Active Zone	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Protein Binding PDZ Domain Binding Small GTPase Binding Leucine Zipper Domain Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone	Scavenger Receptor Activity Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated I-kappaB Phosphorylation Neuromuscular Synaptic Transmission Multicellular Organism Development Protein Transport Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity	Endocytosis Acute-phase Response
Pathways			Scavenging of heme from plasma CD163 mediating an anti-inflammatory response
Drugs			Tetrachlorodecaoxide
Diseases
GWAS		Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)
Interacting Genes		19 interacting genes: APP CD163 CRIP1 DNAJC5 FGF23 FPR2 GALNT8 GPRC5D IFFO1 ITSN2 MRTFB NCAPD2 PPFIA1 PRMT8 RAB6A RAB6B RIMS1 SRPK2 YWHAG	7 interacting genes: CSNK2B ERC1 FCGR1A HOXA1 HP MYH9 PRKCA
Entrez ID		23085	9332
HPRD ID		06181	05708
Ensembl ID		ENSG00000082805	ENSG00000177575
Uniprot IDs		G8JLD3 Q8IUD2 X6RLX0	Q86VB7
PDB IDs
Enriched GO Terms of Interacting Partners?
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