FDFT1 and TMEM43

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FDFT1	TMEM43
Description		farnesyl-diphosphate farnesyltransferase 1	transmembrane protein 43
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Integral Component Of Nuclear Inner Membrane Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity	Protein Binding Identical Protein Binding Protein Self-association
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Farnesyl Diphosphate Metabolic Process	Nuclear Membrane Organization
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs		TAK-475
Diseases
GWAS		Blood protein levels ( 28240269) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Heel bone mineral density ( 30598549) Longevity ( 33657282)
Interacting Genes		26 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 ELP4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35C2 TLCD4 TMEM43 TMX2	16 interacting genes: APOA5 ARL13B CARD10 CISD2 FAM209A FDFT1 FGA FKBP8 GRAMD2B LMNA PCYT1B SCGB1A1 SIAH1 SYNDIG1 USP25 ZCCHC12
Entrez ID		2222	79188
HPRD ID		01694	15541
Ensembl ID		ENSG00000079459	ENSG00000170876
Uniprot IDs		A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1	A0A024R2F9 Q9BTV4
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5
Enriched GO Terms of Interacting Partners?
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