FDFT1 and NCAPH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FDFT1	NCAPH2
Description		farnesyl-diphosphate farnesyltransferase 1	non-SMC condensin II complex subunit H2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Membrane Cell Junction Intercellular Bridge
	Molecular Function	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity	Chromatin Binding Protein Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Farnesyl Diphosphate Metabolic Process	Mitotic Chromosome Condensation Meiotic Chromosome Condensation T Cell Differentiation In Thymus Mitotic Sister Chromatid Separation Female Meiosis Chromosome Separation
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)	Condensation of Prophase Chromosomes
Drugs		TAK-475
Diseases
GWAS		Blood protein levels ( 28240269) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Cerebrospinal fluid clusterin levels ( 26545630) Chronic lymphocytic leukemia ( 28165464) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell traits ( 23222517) Serum metabolite levels ( 33031748)
Interacting Genes		26 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 ELP4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35C2 TLCD4 TMEM43 TMX2	25 interacting genes: ACTN2 ANKRD46 APOD C4orf3 CTXN3 EGLN3 EMD FDFT1 FOLR1 IGFBP5 LMO2 MAL ODAD4 PRPF31 SNRPC SUMO2 TMEM120B TMEM14C TMEM86A TRAF2 TTC32 TUBB UBIAD1 USHBP1 VAMP5
Entrez ID		2222	29781
HPRD ID		01694	11783
Ensembl ID		ENSG00000079459	ENSG00000025770
Uniprot IDs		A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1	Q6IBW4
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5
Enriched GO Terms of Interacting Partners?
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