FARSA and ABI3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		FARSA	ABI3
Description		phenylalanyl-tRNA synthetase subunit alpha	ABI family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane	Intracellular Anatomical Structure Cytoplasm Postsynaptic Density Membrane Lamellipodium SCAR Complex Dendritic Spine Dendritic Shaft
	Molecular Function	TRNA Binding RNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding	Protein Binding SH3 Domain Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Phenylalanyl-tRNA Aminoacylation Protein Heterotetramerization	Defense Response To Tumor Cell Negative Regulation Of Lamellipodium Assembly Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Regulation Of Dendritic Spine Morphogenesis Regulation Of Postsynaptic Density Assembly Negative Regulation Of Ruffle Assembly Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Cellular Senescence
Pathways		Cytosolic tRNA aminoacylation
Drugs		Phenylalanine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)	Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31619474) Family history of Alzheimer's disease ( 30617256) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: A2M ABI3 APOE COG4 ECSIT ESR1 FARSB GORAB HNRNPR OGT PDCD10 PTEN RNF32 TDGF1	77 interacting genes: ABI2 ABI3BP ACTN3 AGTR1 ARHGAP9 ARMC7 BAIAP2L2 BFSP2 BLOC1S5 CENPQ CEP170P1 CEP44 CYFIP2 DESI1 DTNB DTNBP1 EIF3H EIF3M EMILIN1 ENAH EVL FAM124B FARSA FBF1 GNG13 GOLM1 GRB2 HOMER1 HOMER2 HOMER3 IFT20 IHO1 KANK2 KIAA0408 KIFC3 KLC3 KLC4 KRT13 KRT14 KRT15 KRT24 KRT28 KRT31 KRT35 KRT36 KRT38 MAGEA12 MED29 MIS18A MRFAP1 MRFAP1L1 NCK2 NDEL1 NHSL2 NUP58 OIP5 PAK1 PAK2 PSMA1 RUFY3 RUNX1T1 SH3BP1 SMARCD1 SNAP23 SOS1 STX1A STX2 SUFU TMEM147 TRAF4 TXN2 VARS2 VASP WAS WASF1 WASF2 WASHC1
Entrez ID		2193	51225
HPRD ID		04227	05900
Ensembl ID		ENSG00000179115	ENSG00000108798
Uniprot IDs		Q6IBR2 Q9Y285	Q9P2A4
PDB IDs		3L4G
Enriched GO Terms of Interacting Partners?
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