MECOM and SAP130

		MECOM	SAP130
Description		MDS1 and EVI1 complex locus	Sin3A associated protein 130
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Nuclear Speck Sin3-type Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Differentiation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Histone H3-K9 Methylation Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription	HATs acetylate histones NoRC negatively regulates rRNA expression
Drugs
Diseases
GWAS		Aging (time to event) ( 21782286) Asthma ( 32296059) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 31152163 29403010) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Calcific aortic valve stenosis ( 32141789) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 32902719 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate ( 29403010) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Height ( 31562340) Hematocrit ( 32888494 27863252) Hematology traits ( 30576415) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998 29785010 31959993 30054594) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 25849990 33057200) Nasopharyngeal carcinoma ( 26545403) Neonatal white matter microstructure ( 33009551) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 32888494 27863252) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528) Weight ( 34074324) White blood cell count ( 32888494)	Anti-saccade response ( 29064472) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		17 interacting genes: CLIC3 CREBBP CTBP1 CTBP2 HDAC1 HDAC4 HIC1 KAT2B MBD3 PIK3R3 PRMT1 SAP130 SMAD1 SMAD2 SMAD3 SMAD4 UBE2I	12 interacting genes: ARID4B CCR9 CUL2 GPS1 IWS1 MARCO MECOM MYC NIFK SFT2D3 SGK2 SMAD3
Entrez ID		2122	79595
HPRD ID		01310	18015
Ensembl ID		ENSG00000085276	ENSG00000136715
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112	A0A2R8YDB8 H7BXF5 Q96DP1 Q9H0E3
PDB IDs		6BW3
Enriched GO Terms of Interacting Partners?
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