ERN1 and TAOK3

Number of citations of the paper that reports this interaction (PubMedID 11278723)
195

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ERN1	TAOK3
Description		endoplasmic reticulum to nucleus signaling 1	TAO kinase 3
Image
GO Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex	Cytoplasm Plasma Membrane
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity	Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Transferase Activity Protein Serine Kinase Activity
	Biological Process	Endothelial Cell Proliferation MRNA Cleavage MRNA Catabolic Process Protein Phosphorylation Regulation Of Macroautophagy Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-serine Autophosphorylation IRE1-mediated Unfolded Protein Response Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In MRNA Processing Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Peptidyl-serine Trans-autophosphorylation	MAPK Cascade DNA Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis
Pathways		IRE1alpha activates chaperones IRE1alpha activates chaperones	RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib	Fostamatinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver injury in anti-retroviral drug treated HIV ( 28388302)	Depression ( 33859377) Glucose homeostasis traits ( 25524916) Hip circumference ( 28552196) Loneliness ( 31518406) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Post bronchodilator FEV1 in COPD ( 26634245) Red cell distribution width ( 32888494 27863252) Systemic lupus erythematosus ( 19838195)
Interacting Genes		15 interacting genes: BAK1 BAX CEP112 COPS5 HSP90AA1 HSPA5 MAP3K5 P4HB PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2	5 interacting genes: ATF7 ERN1 LRRK2 SMURF1 TRAF2
Entrez ID		2081	51347
HPRD ID		04943	11620
Ensembl ID		ENSG00000178607	ENSG00000135090
Uniprot IDs		O75460	G3V1Q8 Q9H2K8
PDB IDs		2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC 6W39 6W3A 6W3B 6W3C 6W3E 6W3K	6BDN
Enriched GO Terms of Interacting Partners?
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