ERN1 and CEP112

		ERN1	CEP112
Description		endoplasmic reticulum to nucleus signaling 1	centrosomal protein 112
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex	Cytoplasm Centrosome Plasma Membrane Inhibitory Synapse
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Endothelial Cell Proliferation MRNA Cleavage MRNA Catabolic Process Protein Phosphorylation Regulation Of Macroautophagy Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-serine Autophosphorylation IRE1-mediated Unfolded Protein Response Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In MRNA Processing Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Peptidyl-serine Trans-autophosphorylation	Receptor Localization To Synapse
Pathways		IRE1alpha activates chaperones IRE1alpha activates chaperones
Drugs		N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver injury in anti-retroviral drug treated HIV ( 28388302)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Blood protein levels ( 29875488 28240269 23696881) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159) Chin dimples ( 27182965) Iris color (b* coordinate) ( 30895295) Plateletcrit ( 32888494) Post bronchodilator FEV1 ( 26634245) Total body bone mineral density ( 29304378) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		15 interacting genes: BAK1 BAX CEP112 COPS5 HSP90AA1 HSPA5 MAP3K5 P4HB PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2	2 interacting genes: ERN1 FBXO7
Entrez ID		2081	201134
HPRD ID		04943	11336
Ensembl ID		ENSG00000178607	ENSG00000154240
Uniprot IDs		O75460	F5GYE8 Q8N8E3
PDB IDs		2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC 6W39 6W3A 6W3B 6W3C 6W3E 6W3K
Enriched GO Terms of Interacting Partners?
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