ERBB2 and FGFR4

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (protein complementation assay, fluorescent resonance energy transfer)

		ERBB2	FGFR4
Description		erb-b2 receptor tyrosine kinase 2	fibroblast growth factor receptor 4
Image
GO Annotations	Cellular Component	Nucleus Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane ERBB3:ERBB2 Complex Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm	Extracellular Region Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Transport Vesicle Receptor Complex
	Molecular Function	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Intracellular Signal Transduction Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Targeting To Membrane	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Positive Regulation Of Kinase Activity Glucose Homeostasis Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Protein Autophosphorylation Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding FGFR4 mutant receptor activation FGFR4 ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling Signaling by FGFR4 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib AV-412 Pertuzumab Afatinib Tucatinib Tesevatinib Fostamatinib Brigatinib Margetuximab Zanubrutinib	Heparin Ponatinib Lenvatinib Erdafitinib Pemigatinib
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 27329760) Estimated glomerular filtration rate ( 31451708) Pancreatic ductal adenocarcinoma ( 30541042) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Ulcerative colitis ( 20228799)	Activated partial thromboplastin time ( 22703881) Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 28552196 25282103 31562340) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hip shape (DXA scan) ( 30320955) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Type 2 diabetes ( 32499647 30718926) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412)
Interacting Genes		353 interacting genes: AATK ABCB5 ABL1 ABL2 ACP1 ACP3 ADGRB1 AIP AKAP12 AKT1 ALDOA ALDOC ALK ANKS1A ANKS1B ANXA6 AP3B2 APBB1 APBB3 APLP1 ARF1 ARF5 ARNT ASRGL1 ATP6AP1 ATP6V0C AURKA BAAT BCAR3 BECN1 BLK BLNK BMX BNIP1 BTC CACYBP CALM1 CAV1 CBLC CBR1 CCDC180 CCL7 CCND2 CCT3 CD44 CD82 CDK4 CDK6 CDK8 CDKN2B CDKN2C CEND1 CFAP298 CFL1 CHN1 CISH CKB CLASP2 CLCN6 CLNK COL9A2 COL9A3 CRIP2 CRK CRKL CSDE1 CTNNB1 CXCL8 CYLC2 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DST DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHB1 EPHB2 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERG28 ERRFI1 ESR1 FAIM2 FAM241B FBP1 FBXO7 FER FES FGFR1 FGFR2 FGFR3 FGFR4 FGR FKBP1A FKBP3 FKBP8 FLNB FLT3 FLT4 FRAT2 FZR1 GAB1 GABARAPL1 GABARAPL2 GAPDH GLCE GLIS2 GLRX3 GMPR2 GPM6B GRAP2 GRB10 GRB14 GRB2 GRB7 GRK2 GRM1 GSN HCK HDAC6 HDLBP HGF HLA-A HRAS HSD17B3 HSH2D HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA9 HSPD1 IARS1 IGF1R IL13RA2 IL6ST ILF3 ILKAP INPPL1 INSR INSRR IRF2BP2 IRS1 IRS4 ITGA5 ITGB4 ITK ITPKA ITPR1 JAK1 JAK2 JMJD4 JUP KCTD6 KDELR2 KLC1 KLK5 KRT12 LATS2 LCK LCP2 LGALS8 LPCAT4 LRRC7 LYPD3 MAP2K1 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MDH1 MEPCE MERTK MET MSN MST1R MTCH1 MUC1 MUC4 MUCL1 MYC MYO9A NAT2 NCK1 NCK2 NEFH NF2 NINL NRG1 NTRK1 NTRK2 NTRK3 NUDT16L1 ODF2L PABPC1 PAK1 PDCD11 PDGFRA PDGFRB PEBP1 PGAM1 PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 POLD2 POU6F1 PPA1 PPM1A PPM1F PRDM14 PRDX5 PSAP PSMA1 PSMC3 PSMC3IP PSMD3 PTGES3L-AARSD1 PTK2 PTK2B PTK6 PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAB5C RAF1 RASA1 RASSF1 RBM15B RET RHBDD2 RHOBTB2 RIN1 RIN2 ROR2 RPRML RTN4 S100A11 SAFB2 SELENOK SERPINA3 SFRP4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH2D5 SH3BGRL3 SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SLC7A4 SMAD1 SMIM20 SMPD4 SNAP91 SOCS1 SOCS3 SOCS5 SOCS6 SOS1 SPP1 SRC SRPK1 STAP1 STAT3 STIP1 STK11 STK24 STMN1 STMN2 STUB1 STYK1 STYX SUPT6H SYK SYNM TCEAL2 TEC TGFA TGFB1 THRSP TLN1 TMA7 TMEM134 TMEM230 TNS1 TNS2 TNS3 TOB1 TP53 TRIP6 TRMO TSEN15 TTC9B TTYH2 TVP23B TXK TXN TYMP TYRO3 UBB UPF3A USP2 UTP18 VAPA VAV1 VAV2 VAV3 YES1 YWHAZ ZAP70 ZFAND1 ZMAT2 ZMYND8 ZNF189 ZNF532	85 interacting genes: ABCB5 AKT1 ANGPTL4 ARAF ARNT BECN1 BLID CASC3 CBLC CCND2 CCNE1 CD44 CDH2 CDK4 CDK6 CDKN2A CDKN2B CDKN2C DIRAS3 EPHA2 EPHA4 EPSTI1 ERBB2 ERRFI1 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FZR1 GLCE GLIS2 GRM1 HGF HIF1A IFT80 IGF1R KDELR2 LATS2 LRATD2 MAP2K5 MAP2K6 MAP3K5 MAPK14 MDM4 MET MSH2 MTA3 MYC NF2 NSD3 OSGIN1 PDGFRA PDLIM2 PLCG1 PPP3CA PSMC3IP PTPN11 PTPN12 PTPN6 PTPRR RAF1 RASL10B RASSF1 RNF20 ROS1 SCGB3A1 STAT1 STAT3 STC2 STK11 TEAD2 TERT THRSP TP53 TSC1 TTYH2 WIF1
Entrez ID		2064	2264
HPRD ID		01281	00625
Ensembl ID		ENSG00000141736	ENSG00000160867
Uniprot IDs		F5H1T4 J3QLU9 P04626 X5DNK3	B4DVP5 J3KPQ0 P22455
PDB IDs		1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6LBX 6OGE	1QCT 4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG 5NUD 5NWZ 5XFF 5XFJ 6IUO 6IUP 6J6Y 6JPE 6JPJ 6NVG 6NVH 6NVI 6NVJ 6NVK 6V9C 6YI8
Enriched GO Terms of Interacting Partners?
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