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ERBB2 and SYK
Number of citations of the paper that reports this interaction (PubMedID
16273093
)
258
Data Source:
BioGRID
(pull down, unspecified method)
ERBB2
SYK
Description
erb-b2 receptor tyrosine kinase 2
spleen associated tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Early Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
ERBB3:ERBB2 Complex
Myelin Sheath
Receptor Complex
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
B Cell Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Early Phagosome
Protein-containing Complex
T Cell Receptor Complex
Molecular Function
RNA Polymerase I Core Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Growth Factor Binding
Protein Phosphatase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Interleukin-15 Receptor Binding
Protein Kinase Binding
Phosphatase Binding
Toll-like Receptor Binding
SH2 Domain Binding
Phospholipase Binding
Scaffold Protein Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Positive Regulation Of Cell Population Proliferation
Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Positive Regulation Of Cell Growth
Regulation Of Microtubule-based Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Kinase Activity
Intracellular Signal Transduction
Wound Healing
Myelination
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of GTPase Activity
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase I
Protein Autophosphorylation
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Protein Targeting To Membrane
Angiogenesis
Cell Activation
Lymph Vessel Development
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Leukocyte Activation Involved In Immune Response
Serotonin Secretion By Platelet
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Protein Phosphorylation
Protein Import Into Nucleus
Leukocyte Cell-cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Animal Organ Morphogenesis
Regulation Of Platelet Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Leukotriene Biosynthetic Process
Cell Differentiation
Platelet Activation
Neutrophil Chemotaxis
Positive Regulation Of Protein-containing Complex Assembly
Receptor Internalization
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-3 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Interleukin-3-mediated Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
Regulation Of Neutrophil Degranulation
Beta Selection
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Bone Resorption
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Protein Autophosphorylation
Blood Vessel Morphogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
B Cell Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Killing Of Cells Of Other Organism
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Molecule Of Fungal Origin
Cellular Response To Lipid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Arachidonic Acid Secretion
Regulation Of Platelet Aggregation
Positive Regulation Of Cold-induced Thermogenesis
Cellular Response To Lectin
Pathways
Signaling by ERBB2
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
GPVI-mediated activation cascade
GPVI-mediated activation cascade
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Integrin signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Trastuzumab
Lapatinib
IGN311
Trastuzumab emtansine
Varlitinib
AV-412
Pertuzumab
Afatinib
Tucatinib
Tesevatinib
Fostamatinib
Brigatinib
Margetuximab
Zanubrutinib
Staurosporine
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
Tamatinib
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Ellagic acid
Fostamatinib
Diseases
GWAS
Adult asthma (
30787307
)
Asthma (
31619474
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
27329760
)
Estimated glomerular filtration rate (
31451708
)
Pancreatic ductal adenocarcinoma (
30541042
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
28714469
)
Ulcerative colitis (
20228799
)
Alzheimer's disease (
30636644
)
Anti-saccade response (
29064472
)
Atrial fibrillation (
28416822
)
Chromosomal aberration frequency (total) (
31586183
)
Frontal pole volume (
31530798
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Type 2 diabetes (
22456796
)
Vascular dementia (
23480133
)
Interacting Genes
353 interacting genes:
AATK
ABCB5
ABL1
ABL2
ACP1
ACP3
ADGRB1
AIP
AKAP12
AKT1
ALDOA
ALDOC
ALK
ANKS1A
ANKS1B
ANXA6
AP3B2
APBB1
APBB3
APLP1
ARF1
ARF5
ARNT
ASRGL1
ATP6AP1
ATP6V0C
AURKA
BAAT
BCAR3
BECN1
BLK
BLNK
BMX
BNIP1
BTC
CACYBP
CALM1
CAV1
CBLC
CBR1
CCDC180
CCL7
CCND2
CCT3
CD44
CD82
CDK4
CDK6
CDK8
CDKN2B
CDKN2C
CEND1
CFAP298
CFL1
CHN1
CISH
CKB
CLASP2
CLCN6
CLNK
COL9A2
COL9A3
CRIP2
CRK
CRKL
CSDE1
CTNNB1
CXCL8
CYLC2
CYP17A1
DAB1
DDR1
DLG4
DOK1
DOK4
DOK6
DST
DUSP14
DUSP18
DUSP19
EGF
EGFR
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHB1
EPHB2
EPHB3
EPHB6
ERBB3
ERBB4
ERBIN
ERG28
ERRFI1
ESR1
FAIM2
FAM241B
FBP1
FBXO7
FER
FES
FGFR1
FGFR2
FGFR3
FGFR4
FGR
FKBP1A
FKBP3
FKBP8
FLNB
FLT3
FLT4
FRAT2
FZR1
GAB1
GABARAPL1
GABARAPL2
GAPDH
GLCE
GLIS2
GLRX3
GMPR2
GPM6B
GRAP2
GRB10
GRB14
GRB2
GRB7
GRK2
GRM1
GSN
HCK
HDAC6
HDLBP
HGF
HLA-A
HRAS
HSD17B3
HSH2D
HSP90AA1
HSP90B1
HSPA1A
HSPA5
HSPA9
HSPD1
IARS1
IGF1R
IL13RA2
IL6ST
ILF3
ILKAP
INPPL1
INSR
INSRR
IRF2BP2
IRS1
IRS4
ITGA5
ITGB4
ITK
ITPKA
ITPR1
JAK1
JAK2
JMJD4
JUP
KCTD6
KDELR2
KLC1
KLK5
KRT12
LATS2
LCK
LCP2
LGALS8
LPCAT4
LRRC7
LYPD3
MAP2K1
MAP2K3
MAP2K5
MAPK8IP1
MAPK8IP2
MATK
MDH1
MEPCE
MERTK
MET
MSN
MST1R
MTCH1
MUC1
MUC4
MUCL1
MYC
MYO9A
NAT2
NCK1
NCK2
NEFH
NF2
NINL
NRG1
NTRK1
NTRK2
NTRK3
NUDT16L1
ODF2L
PABPC1
PAK1
PDCD11
PDGFRA
PDGFRB
PEBP1
PGAM1
PHF23
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
POLD2
POU6F1
PPA1
PPM1A
PPM1F
PRDM14
PRDX5
PSAP
PSMA1
PSMC3
PSMC3IP
PSMD3
PTGES3L-AARSD1
PTK2
PTK2B
PTK6
PTK7
PTPN11
PTPN18
PTPN6
PTPRR
PTPRT
PTPRU
RAB5C
RAF1
RASA1
RASSF1
RBM15B
RET
RHBDD2
RHOBTB2
RIN1
RIN2
ROR2
RPRML
RTN4
S100A11
SAFB2
SELENOK
SERPINA3
SFRP4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH2D5
SH3BGRL3
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SLC7A4
SMAD1
SMIM20
SMPD4
SNAP91
SOCS1
SOCS3
SOCS5
SOCS6
SOS1
SPP1
SRC
SRPK1
STAP1
STAT3
STIP1
STK11
STK24
STMN1
STMN2
STUB1
STYK1
STYX
SUPT6H
SYK
SYNM
TCEAL2
TEC
TGFA
TGFB1
THRSP
TLN1
TMA7
TMEM134
TMEM230
TNS1
TNS2
TNS3
TOB1
TP53
TRIP6
TRMO
TSEN15
TTC9B
TTYH2
TVP23B
TXK
TXN
TYMP
TYRO3
UBB
UPF3A
USP2
UTP18
VAPA
VAV1
VAV2
VAV3
YES1
YWHAZ
ZAP70
ZFAND1
ZMAT2
ZMYND8
ZNF189
ZNF532
107 interacting genes:
APP
AR
BLNK
BTK
CALM1
CBL
CBLB
CD19
CD22
CD3E
CD72
CD79A
CD79B
COASY
CRKL
CSF2RB
CSF3R
CTTN
DBNL
DPP9
DUSP3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
FCER1G
FCGR1A
FCGR2A
FCGR3A
FCRL3
FGR
FYN
GAB1
GAB2
GRB2
HCLS1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC9
HGS
HNRNPU
IL15RA
IL2RB
ITGB2
JAK1
KIT
LAT
LAX1
LCK
LCP2
LYN
MAP4K1
MAPK3
MAPT
MET
MS4A2
NEDD4
NFAM1
PAG1
PIK3AP1
PIK3R1
PIK3R2
PLCG1
PLCG2
POU2AF1
PRKCA
PRKD1
PTK2
PTK2B
PTPN6
PXN
RASA1
RHOU
RPS10
RPS6KA1
RPS6KB1
RPS6KB2
SELPLG
SH2B2
SH2D2A
SH3BP2
SHC1
SIT1
SLA
SLC4A1
SNCA
SRC
STAT1
STAT3
STAT5A
TERF1
TLR4
TNFRSF1A
TRAF6
TRIM15
TUBA1A
TUBA4A
TYROBP
UBASH3B
UBB
USP25
VAV1
VAV2
Entrez ID
2064
6850
HPRD ID
01281
02514
Ensembl ID
ENSG00000141736
ENSG00000165025
Uniprot IDs
F5H1T4
J3QLU9
P04626
X5DNK3
A0A024R244
A0A024R273
P43405
PDB IDs
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
2A91
2JWA
2KS1
2L4K
2N2A
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
3WLW
3WSQ
4GFU
4HRL
4HRM
4HRN
5K33
5KWG
5MY6
5O4G
5OB4
5TQS
6ATT
6BGT
6J71
6LBX
6OGE
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
5Y5T
5Y5U
6HM6
6HM7
6SSB
6VOV
Enriched GO Terms of Interacting Partners
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