EGR4 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 30385546)
64

Data Source:
BioGRID (pull down)

		EGR4	CRBN
Description		early growth response 4	cereblon
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II	Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Large Conductance Calcium-activated Potassium Channel Activity
Pathways		NGF-stimulated transcription	Potential therapeutics for SARS
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases
GWAS		Age at voice drop ( 27182965) Blood metabolite levels ( 26401656) Retinitis pigmentosa ( 33514863)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		6 interacting genes: ABI2 BAG3 CRBN DNMT3L GPX4 NFATC2	38 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CUL4B CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		1961	51185
HPRD ID		00550	16750
Ensembl ID		ENSG00000135625	ENSG00000113851
Uniprot IDs		B7ZKU3 Q05215	Q96SW2
PDB IDs			4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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