EEF1A2 and UBE3A

Number of citations of the paper that reports this interaction (PubMedID 31329371)
1

Data Source:
BioGRID (pull down)

		EEF1A2	UBE3A
Description		eukaryotic translation elongation factor 1 alpha 2	ubiquitin protein ligase E3A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Eukaryotic Translation Elongation Factor 1 Complex Neuronal Cell Body Synapse Cytoplasmic Side Of Lysosomal Membrane	Proteasome Complex Nucleus Cytosol
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Protein Kinase Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Translation Translational Elongation Response To Inorganic Substance Positive Regulation Of Apoptotic Process Response To Electrical Stimulus Positive Regulation Of Lipid Kinase Activity Regulation Of Chaperone-mediated Autophagy	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Locomotory Exploration Behavior Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Motor Learning Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Eukaryotic Translation Elongation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 23535732) Serum metabolite levels ( 33031748)	Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		11 interacting genes: ABTB1 CHRM4 ERG MAPK6 SMN1 STK11 SUMO2 TPT1 TSPY1 TTLL12 UBE3A	150 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CTNNB1 DAZAP2 DLG1 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM7 MDM1 MDM2 MEOX2 MSTO1 MYCBP NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446
Entrez ID		1917	7337
HPRD ID		04265	03375
Ensembl ID		ENSG00000101210	ENSG00000114062
Uniprot IDs		Q05639	Q05086 Q9H2G0
PDB IDs		3C5J	1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19
Enriched GO Terms of Interacting Partners?
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