AGT and MME

Number of citations of the paper that reports this interaction (PubMedID 15283675)
241

Data Source:
BioGRID (enzymatic study)

		AGT	MME
Description		angiotensinogen	membrane metalloendopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Cytoplasm Early Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Integral Component Of Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding	Phosphatidylserine Binding Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Peptide Binding Protein Homodimerization Activity Oligopeptidase Activity Cardiolipin Binding
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Regulation Of Heart Rate Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Renal System Process Angiotensin-mediated Drinking Behavior Positive Regulation Of Extracellular Matrix Constituent Secretion Protein Import Into Nucleus Cellular Sodium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Cell-cell Signaling Female Pregnancy Aging Regulation Of Blood Pressure Associative Learning Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Regulation Of Norepinephrine Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Angiogenesis Regulation Of Vasoconstriction Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Tissue Remodeling Low-density Lipoprotein Particle Remodeling Operant Conditioning Regulation Of Renal Sodium Excretion Positive Regulation Of Renal Sodium Excretion Regulation Of Cell Population Proliferation Vasodilation Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Calcium Ion Transport Regulation Of Transmission Of Nerve Impulse Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Tyrosine Kinase Activity ERK1 And ERK2 Cascade Uterine Smooth Muscle Contraction Cellular Response To Mechanical Stimulus Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Extracellular Matrix Assembly Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of L-lysine Import Across Plasma Membrane Positive Regulation Of L-arginine Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Aging Learning Or Memory Protein Processing Sensory Perception Of Pain Lung Development Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation
Pathways		PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs		Zinc Copper Sparsentan Zinc acetate	Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pancreatic ductal adenocarcinoma ( 30541042) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		24 interacting genes: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB HSP90AA1 ITSN2 KNG1 LNPEP MAS1 MEP1A MME PRCP PREP PRG2 REN TP53	18 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 VIP
Entrez ID		183	4311
HPRD ID		00106	00392
Ensembl ID		ENSG00000135744	ENSG00000196549
Uniprot IDs		B0ZBE2 B2R5S1 P01019	P08473
PDB IDs		1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS 5E2Q 5M3X 5M3Y 5XJM 6I3F 6I3I 6JOD 6OS0 7C6A	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?