AGT and REN

Number of citations of the paper that reports this interaction (PubMedID 12045255)
385

Data Source:
BioGRID (enzymatic study, x-ray crystallography, enzymatic study)

		AGT	REN
Description		angiotensinogen	renin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Apical Part Of Cell
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding	Aspartic-type Endopeptidase Activity Signaling Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Peptidase Activity
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Regulation Of Heart Rate Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Renal System Process Angiotensin-mediated Drinking Behavior Positive Regulation Of Extracellular Matrix Constituent Secretion Protein Import Into Nucleus Cellular Sodium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Cell-cell Signaling Female Pregnancy Aging Regulation Of Blood Pressure Associative Learning Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Regulation Of Norepinephrine Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Angiogenesis Regulation Of Vasoconstriction Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Tissue Remodeling Low-density Lipoprotein Particle Remodeling Operant Conditioning Regulation Of Renal Sodium Excretion Positive Regulation Of Renal Sodium Excretion Regulation Of Cell Population Proliferation Vasodilation Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Calcium Ion Transport Regulation Of Transmission Of Nerve Impulse Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Tyrosine Kinase Activity ERK1 And ERK2 Cascade Uterine Smooth Muscle Contraction Cellular Response To Mechanical Stimulus Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Extracellular Matrix Assembly Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of L-lysine Import Across Plasma Membrane Positive Regulation Of L-arginine Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Kidney Development Mesonephros Development Angiotensin Maturation Renin-angiotensin Regulation Of Aldosterone Production Proteolysis Regulation Of Blood Pressure Male Gonad Development Hormone-mediated Signaling Pathway Response To Lipopolysaccharide Response To Immobilization Stress Drinking Behavior Regulation Of MAPK Cascade Cell Maturation Amyloid-beta Metabolic Process Response To CAMP Response To CGMP Cellular Response To Xenobiotic Stimulus
Pathways		PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Metabolism of Angiotensinogen to Angiotensins
Drugs		Zinc Copper Sparsentan Zinc acetate	Remikiren Minoxidil Lisinopril N,N-dimethylformamide Isoamyl alcohol 3-Phenyl-1,2-Propandiol 2-Methyl-3-(2-Aminothiazolo)Propanal Enalkiren 2-Cyclopropylmethylenepropanal 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine N-Methyl-N-(Methylbenzyl)Formamide 1-Hydroxy-2-Amino-3-Cyclohexylpropane SPP1148 ZOTHIAZIN-4-YL]ETHYL}ACETAMIDE 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE 6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine Aliskiren
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pancreatic ductal adenocarcinoma ( 30541042) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Blood protein levels ( 29875488) Blood protein levels in cardiovascular risk ( 28369058) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		24 interacting genes: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB HSP90AA1 ITSN2 KNG1 LNPEP MAS1 MEP1A MME PRCP PREP PRG2 REN TP53	9 interacting genes: AGT ATP6AP2 CCDC24 CTSB KCTD15 M6PR PCSK1 PCSK5 RENBP
Entrez ID		183	5972
HPRD ID		00106	01564
Ensembl ID		ENSG00000135744	ENSG00000143839
Uniprot IDs		B0ZBE2 B2R5S1 P01019	P00797
PDB IDs		1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS 5E2Q 5M3X 5M3Y 5XJM 6I3F 6I3I 6JOD 6OS0 7C6A	1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 2X0B 3D91 3G6Z 3G70 3G72 3GW5 3K1W 3KM4 3O9L 3OAD 3OAG 3OOT 3OQF 3OQK 3OWN 3Q3T 3Q4B 3Q5H 3SFC 3VCM 3VSW 3VSX 3VUC 3VYD 3VYE 3VYF 4AMT 4GJ5 4GJ6 4GJ7 4GJ8 4GJ9 4GJA 4GJB 4GJC 4GJD 4PYV 4Q1N 4RYC 4RYG 4RZ1 4S1G 4XX3 4XX4 5KOQ 5KOS 5KOT 5SXN 5SY2 5SY3 5SZ9 5T4S 5TMG 5TMK 5V8V 5VPM 5VRP 6I3F
Enriched GO Terms of Interacting Partners?
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