MME and EDN1

Number of citations of the paper that reports this interaction (PubMedID 2201681)
46

Data Source:
HPRD (in vitro)

		MME	EDN1
Description		membrane metalloendopeptidase	endothelin 1
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Integral Component Of Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse	Extracellular Region Extracellular Space Cytoplasm Transport Vesicle Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Peptide Binding Protein Homodimerization Activity Oligopeptidase Activity Cardiolipin Binding	Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding
	Biological Process	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Aging Learning Or Memory Protein Processing Sensory Perception Of Pain Lung Development Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Histamine Secretion Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Regulation Of PH Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Heart Development Respiratory Gaseous Exchange By Respiratory System Body Fluid Secretion Positive Regulation Of Cell Population Proliferation Dorsal/ventral Pattern Formation Response To Ozone Multicellular Organism Aging Positive Regulation Of Heart Rate Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Regulation Of Glucose Transmembrane Transport Neural Crest Cell Development Phosphatidylinositol 3-kinase Signaling Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Sensory Perception Of Pain Calcium-mediated Signaling Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Response To Nicotine Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Protein Kinase C Deactivation Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAP Kinase Activity Positive Regulation Of JUN Kinase Activity Response To Leptin Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Cartilage Development Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Membrane Depolarization Regulation Of Sensory Perception Of Pain Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Calcium Ion Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Endothelin Receptor Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of NIK/NF-kappaB Signaling Response To Salt Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Signaling Receptor Activity
Pathways		Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat	TBC-3711
Diseases
GWAS		Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)	Body mass index ( 26426971) Circulating vasoactive peptide levels ( 23381795) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematocrit ( 32888494) Hemoglobin ( 32888494) Multiple system atrophy ( 27629089) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494)
Interacting Genes		18 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 VIP	10 interacting genes: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4
Entrez ID		4311	1906
HPRD ID		00392	07030
Ensembl ID		ENSG00000196549	ENSG00000078401
Uniprot IDs		P08473	P05305 Q6FH53
PDB IDs		1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP	1EDN 1EDP 1T7H 1V6R 5GLH 6DK5
Enriched GO Terms of Interacting Partners?
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