DSG1 and DSC2

Number of citations of the paper that reports this interaction (PubMedID 9443898)
28

Data Source:
HPRD (in vivo)

		DSG1	DSC2
Description		desmoglein 1	desmocollin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Desmosome Ficolin-1-rich Granule Membrane	Cornified Envelope Plasma Membrane Cell-cell Junction Intercalated Disc Integral Component Of Membrane Desmosome Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding	Calcium Ion Binding Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Stabilization Cell-cell Adhesion	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Eosinophilic esophagitis (pediatric) ( 20208534) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169) Yeast infection ( 28928442)	Blood protein levels ( 30072576 29875488) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738)
Interacting Genes		8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3	12 interacting genes: CDC6 CELF4 CLK1 DSC3 DSG1 DSG2 FHOD3 ITSN1 JUP PKP2 PKP3 RO60
Entrez ID		1828	1824
HPRD ID		00515	00512
Ensembl ID		ENSG00000134760	ENSG00000134755
Uniprot IDs		Q02413	A0A3B3ISU0 Q02487
PDB IDs			5ERP 5J5J 7A7D
Enriched GO Terms of Interacting Partners?
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