HELLS and H1-2

Number of citations of the paper that reports this interaction (PubMedID 33288900)
2

Data Source:
BioGRID (pull down)

		HELLS	H1-2
Description		helicase, lymphoid specific	H1.2 linker histone, cluster member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin	Nucleosome Euchromatin Nucleus Transcriptionally Active Chromatin
	Molecular Function	Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP-dependent Chromatin Remodeler Activity	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Urogenital System Development DNA Methylation DNA Methylation-dependent Heterochromatin Assembly Cell Cycle Multicellular Organism Development Maintenance Of DNA Methylation Pericentric Heterochromatin Assembly Lymphocyte Proliferation Cell Division Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		10 interacting genes: APP DNMT1 DNMT3B E2F3 GPAT4-AS1 GTSF1L H1-2 HDAC1 MEOX2 SERTAD2	29 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 HELLS IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12 YBX1
Entrez ID		3070	3006
HPRD ID		07232	07514
Ensembl ID		ENSG00000119969	ENSG00000187837
Uniprot IDs		A0A087WSW7 A0A0B4J1V9 F6XU50 Q0VGL2 Q76H82 Q9NRZ9	P16403
PDB IDs
Enriched GO Terms of Interacting Partners?
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