DYNC1I2 and DYNLT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		DYNC1I2	DYNLT1
Description		dynein cytoplasmic 1 intermediate chain 2	dynein light chain Tctex-type 1
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle	Extracellular Region Cytoplasm Mitochondrion Golgi Apparatus Spindle Cytoplasmic Dynein Complex Cytoplasmic Microtubule Lamellipodium Secretory Granule Lumen Neuronal Cell Body Host Cell Axonal Growth Cone Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Microtubule-based Movement Transport Along Microtubule	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Dendrite Development Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Regulation Of GTPase Activity Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axon Development Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Neutrophil degranulation
Drugs
Diseases
GWAS		Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		13 interacting genes: ACTN3 ATP5MC3 CCDC136 CDCA7 DCTN1 DYNLRB1 DYNLT1 DYNLT3 HOXD1 HOXD8 NECAB2 PNN PPFIA1	57 interacting genes: ACAT2 ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 CRHBP DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 DYNLT2B DYNLT3 ERO1A FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PRKN PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RPS6KA2 RRAGA SDCBP SIRPA SVIL SYNJ2 TCEANC TMEM143 TROAP TUBA3C TXN UXT VDAC1 XRN2
Entrez ID		1781	6993
HPRD ID		04512	15987
Ensembl ID		ENSG00000077380	ENSG00000146425
Uniprot IDs		A0A140VKE9 B4DPZ3 Q13409	P63172
PDB IDs		5JPW 6F1T 6F1U 6F1Z 6F38 6F3A	5JPW
Enriched GO Terms of Interacting Partners?
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