DNA2 and BLM

Number of citations of the paper that reports this interaction (PubMedID 31153714)
17

Data Source:
BioGRID (pull down)

		DNA2	BLM
Description		DNA replication helicase/nuclease 2	BLM RecQ like helicase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Nucleoid	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Protein-containing Complex
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Nuclease Activity Protein Binding ATP Binding ATP Hydrolysis Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base 5'-flap Endonuclease Activity Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding P53 Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding DNA/DNA Annealing Activity
	Biological Process	DNA Replication Checkpoint Signaling Telomere Maintenance DNA Double-strand Break Processing DNA Replication Mitochondrial DNA Replication Base-excision Repair Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding DNA Replication, Okazaki Fragment Processing DNA Replication, Removal Of RNA Primer Mitochondrial DNA Repair G-quadruplex DNA Unwinding Positive Regulation Of DNA Replication Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Mitotic Telomere Maintenance Via Semi-conservative Replication	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding G-quadruplex DNA Unwinding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Recombination Replication Fork Protection Protein Complex Oligomerization Protein Homooligomerization Negative Regulation Of Cell Division Telomeric D-loop Disassembly Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin Regulation Of DNA-dependent DNA Replication T-circle Formation
Pathways		Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Processive synthesis on the C-strand of the telomere SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Coronary artery disease ( 32469254) Daytime sleep phenotypes ( 27126917)
Interacting Genes		3 interacting genes: BLM RBBP8 TRAF6	40 interacting genes: ACAN ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 DNA2 EXO1 FANCD2 FBXW7 FEN1 FES JUN MCRS1 MIB1 MLH1 MX1 NEK11 PSMD3 RAD51 RAD51D RNF8 RPA1 SMC1A SPIDR SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TOPBP1 TP53 TP53BP1 TRIM49 UBE2I UPF2 WRN
Entrez ID		1763	641
HPRD ID		19123	05211
Ensembl ID		ENSG00000138346	ENSG00000197299
Uniprot IDs		P51530	B7ZKN7 H0YNU5 P54132
PDB IDs		5EAY	2KV2 2MH9 2RRD 3WE2 3WE3 4CDG 4CGZ 4O3M 5LUP 5MK5 5U6K 7AUC 7AUD
Enriched GO Terms of Interacting Partners?
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