DNM1 and SH3GL3

Number of citations of the paper that reports this interaction (PubMedID 9238017)
123

Data Source:
HPRD (in vivo, in vitro)

		DNM1	SH3GL3
Description		dynamin 1	SH3 domain containing GRB2 like 3, endophilin A3
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleoplasm Cytoplasm Golgi Apparatus Microtubule Plasma Membrane Synaptic Vesicle Membrane Membrane Coat Varicosity Synapse Extracellular Exosome Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone Membrane Glutamatergic Synapse	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	RNA Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Protein C-terminus Binding SH3 Domain Binding Protein Kinase Binding D2 Dopamine Receptor Binding Identical Protein Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Internalization Endocytosis Receptor-mediated Endocytosis Endosome Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Synaptic Vesicle Endocytosis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Endocytosis Toxin Transport Response To Amyloid-beta	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Clathrin-mediated endocytosis	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Body mass index ( 26426971) Coenzyme Q10 levels ( 27149984) Platelet distribution width ( 32888494)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Smoking initiation ( 33082346) Spine bone size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)
Interacting Genes		47 interacting genes: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CEP126 CLIC3 CLIC4 CLINT1 CTTN DNM2 DNMBP EPS15 FNBP1 GRB2 GRIN1 GRIN2D ITSN1 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PRKCA PRNP RACK1 SH3GL1 SH3GL2 SH3GL3 SHANK2 SNAP25 SNX9 SRC SUMO1 TIMM50 UBE2I	52 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHANK3 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33
Entrez ID		1759	6457
HPRD ID		03851	04528
Ensembl ID		ENSG00000106976	ENSG00000140600
Uniprot IDs		B4DK06 B7ZAC0 Q05193	A0A024R215 Q99963
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS 4UUD 4UUK 5D3Q 6DLU 6DLV 6S9A	2EW3 2Z0V
Enriched GO Terms of Interacting Partners?
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