SH3GL3 and ARHGDIA

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SH3GL3	ARHGDIA
Description		SH3 domain containing GRB2 like 3, endophilin A3	Rho GDP dissociation inhibitor alpha
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GO Annotations	Cellular Component	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Immunological Synapse Nucleus Cytosol Cytoskeleton Membrane Synapse Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Fatty Acid Binding Protein Binding Protein Kinase Binding Small GTPase Binding Hsp90 Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Cell Shape Negative Regulation Of Cell Migration Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Redox State Semaphorin-plexin Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription	Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Smoking initiation ( 33082346) Spine bone size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)
Interacting Genes		52 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHANK3 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33	41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		6457	396
HPRD ID		04528	03565
Ensembl ID		ENSG00000140600	ENSG00000141522
Uniprot IDs		A0A024R215 Q99963	J3QQX2 P52565 V9HWE8
PDB IDs		2EW3 2Z0V	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80
Enriched GO Terms of Interacting Partners?
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