AKR1C1 and TNFRSF18

		AKR1C1	TNFRSF18
Description		aldo-keto reductase family 1 member C1	TNF receptor superfamily member 18
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Carboxylic Acid Binding Bile Acid Binding 3beta-hydroxy-5beta-steroid Dehydrogenase Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Androsterone Dehydrogenase (B-specific) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity D-threo-aldose 1-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Tumor Necrosis Factor-activated Receptor Activity Protein Binding
	Biological Process	Retinoid Metabolic Process Prostaglandin Metabolic Process Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Response To Organophosphorus Cellular Response To Jasmonic Acid Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Retinoid metabolism and transport	TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs		NADH Salicylic acid Acetylsalicylic acid Nicotinamide adenine dinucleotide phosphate Naringenin 2-HYDROXY-3,5-DIIODOBENZOIC ACID Epitestosterone Hexestrol
Diseases
GWAS		Blood protein levels ( 29875488) Economic and political preferences (immigration/crime) ( 22566634) Height ( 25282103) Hip index ( 34021172) Hypopharyngeal or laryngeal cancer ( 32276964) Lung cancer ( 28604730) Metabolite levels ( 23823483) Squamous cell lung carcinoma ( 28604730) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Inflammatory bowel disease ( 23128233)
Interacting Genes		5 interacting genes: COMMD8 MAPK3 PTPN3 SUFU TNFRSF18	13 interacting genes: AKR1C1 ARHGEF16 BTK DZIP3 KCNAB2 LGALS8 LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2 WRAP73
Entrez ID		1645	8784
HPRD ID		07194	04879
Ensembl ID		ENSG00000187134	ENSG00000186891
Uniprot IDs		Q04828	A0A0R7FDM1 Q9Y5U5
PDB IDs		1MRQ 3C3U 3GUG 3NTY 4YVP 6A7A 6IJX	7KHD
Enriched GO Terms of Interacting Partners?
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