AKR1C1 and PTPN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AKR1C1	PTPN3
Description		aldo-keto reductase family 1 member C1	protein tyrosine phosphatase non-receptor type 3
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Carboxylic Acid Binding Bile Acid Binding 3beta-hydroxy-5beta-steroid Dehydrogenase Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Androsterone Dehydrogenase (B-specific) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity D-threo-aldose 1-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	Retinoid Metabolic Process Prostaglandin Metabolic Process Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Response To Organophosphorus Cellular Response To Jasmonic Acid Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process	MAPK Cascade Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Retinoid metabolism and transport	EGFR downregulation Negative regulation of MAPK pathway
Drugs		NADH Salicylic acid Acetylsalicylic acid Nicotinamide adenine dinucleotide phosphate Naringenin 2-HYDROXY-3,5-DIIODOBENZOIC ACID Epitestosterone Hexestrol
Diseases
GWAS		Blood protein levels ( 29875488) Economic and political preferences (immigration/crime) ( 22566634) Height ( 25282103) Hip index ( 34021172) Hypopharyngeal or laryngeal cancer ( 32276964) Lung cancer ( 28604730) Metabolite levels ( 23823483) Squamous cell lung carcinoma ( 28604730) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		5 interacting genes: COMMD8 MAPK3 PTPN3 SUFU TNFRSF18	27 interacting genes: ACE2 ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		1645	5774
HPRD ID		07194	06767
Ensembl ID		ENSG00000187134	ENSG00000070159
Uniprot IDs		Q04828	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs		1MRQ 3C3U 3GUG 3NTY 4YVP 6A7A 6IJX	2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS 6T36
Enriched GO Terms of Interacting Partners?
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