AKR1C1 and COMMD8

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		AKR1C1	COMMD8
Description		aldo-keto reductase family 1 member C1	COMM domain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleoplasm Cytosol
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Carboxylic Acid Binding Bile Acid Binding 3beta-hydroxy-5beta-steroid Dehydrogenase Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Androsterone Dehydrogenase (B-specific) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity D-threo-aldose 1-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Protein Binding
	Biological Process	Retinoid Metabolic Process Prostaglandin Metabolic Process Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Response To Organophosphorus Cellular Response To Jasmonic Acid Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Retinoid metabolism and transport	Neddylation
Drugs		NADH Salicylic acid Acetylsalicylic acid Nicotinamide adenine dinucleotide phosphate Naringenin 2-HYDROXY-3,5-DIIODOBENZOIC ACID Epitestosterone Hexestrol
Diseases
GWAS		Blood protein levels ( 29875488) Economic and political preferences (immigration/crime) ( 22566634) Height ( 25282103) Hip index ( 34021172) Hypopharyngeal or laryngeal cancer ( 32276964) Lung cancer ( 28604730) Metabolite levels ( 23823483) Squamous cell lung carcinoma ( 28604730) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		5 interacting genes: COMMD8 MAPK3 PTPN3 SUFU TNFRSF18	7 interacting genes: AKR1C1 COMMD1 COMMD4 NDUFA4L2 TEC TMX2 ZNF474
Entrez ID		1645	54951
HPRD ID		07194	13086
Ensembl ID		ENSG00000187134	ENSG00000169019
Uniprot IDs		Q04828	Q9NX08
PDB IDs		1MRQ 3C3U 3GUG 3NTY 4YVP 6A7A 6IJX
Enriched GO Terms of Interacting Partners?
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